Hyderabad: From IIT hyderabad oral drug to be treated black fungus .

The Indian Institute of Technology-Hyderabad has developed nano fibre-based, controlled-release oral tablets of amphotericin B (AmB) to treat post-Covid fungal infections. Researchers have kept the technology free of intellectual property rights and are looking for pharmaceutical partners who can take up mass-scale production. Currently, AmB is an injectible drug.
In 2019, faculty members Saptarshi Majumdar and Chandra Shekhar Sharma from the department of chemical engineering had released a study that oral nanofibrous AmB can be effective to treat kala azar, a parasitic ailment that can cause fever, weight loss and swelling of the liver or the spleen. This was a first-ever attempt to fabricate nano fibrous oral tablets of amphotericin B for the potential cure of kala azar or leishmaniasis.Two years later, the researchers say they are confident the technology can be transferred to suitable pharma partners for large-scale production. At present, kala azar treatment is being used to treat black and other fungi and its availability and affordability make it necessary to allow emergency and immediate trial of this oral drug.

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